Novel use of cranial epidural space in rabbits as an animal model to investigate bone volume augmentation potential of different bone graft substitutes

Table 1 Distribution of bone tissue observed inside experimental cranial epidural space identified by BS-SEM [17, 18]

Tissue		Sample with β-TCP	Sample with BCP
Bone tissue/Total observed area × 100		63.6% +/− 8.7 *	48.5% +/− 9.4
Vascular and Medullary cavity/Total observed area × 100		29.5% +/− 8.4	38.2% +/− 7.2
Characteristics of bone tissue	Chondroid/tissue Total bone area × 100	5.1% +/− 2.2	3.1% +/− 3
	Woven bone/Total bone area × 100	19.3% +/− 6.2	16.4% +/− 8.1
	Lamellar bone/Total bone area × 100	78.4% +/− 9.5	85.7% +/− 13.3

Percentage distribution of tissues observed in the experimental samples by BS-SEM. The “total observed area” involves all of tissue observed in the epidural space including biomaterial particles, in a frontal cut of sample (as showed in Fig. 2). The “total bone area” involves only the bone tissue (without biomaterial particles) observed in a frontal cut of samples. BCP samples reveal a more mature profile of osseous tissue than β-TCP with higher amounts of lamellar bone, albeit the difference is not significant
*Significant difference (p<0,05)

ISSN: 1746-160X